myself I run 2 cell batteries, but never come near running them dead. I just do it every few charges, it was just a discussion at our track after the races last night.depends on what cell batteries and how far you are discharging them.
We mostly run 2 cell and no one runs them completely dead or even near lipo cut off so they never come out of balance. I went most of the summer with out balance charging any of my 2 cells. I checked the voltage and they were all still with in .002 volts. If your a guy that constantly runs the packs to 3.0 volts per cell I would balance it every couple charges.